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Several clues converge to hypothesize that peripheral danger presentation can trigger off a fast arousal network potentially independent of the consciousness spot.
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Sometimes these puzzles simply fizzle out, and other times they converge, but rarely in ways that allow readers to see the clues being assembled — if there are any clues to be found at all.
Here, we draw on clues from two independent approaches, an unbiased genetic screen and structure/activity analyses of ISRIB, to converge on the hypothesis that the mammalian eIF2B complex indeed is the molecular target of ISRIB.
Although blunting inflammation would not restore the primary defect, the emerging clue is that multiple strategies, addressing different aspects of the pathology, which may eventually converge, may be successful.
In truth, the clues are various, and political fortunes and cultural trends tend most often to veer off at sharp angles from each other, not to converge.
Those conditions rarely converge.
Short-term interests converge.
Events start to converge.
The two must converge.
Do their interests converge?
They converge at Washington.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com