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This study provides a new clue for the development of novel antitubercular lead molecules.
This study provides a new structural clue for the development of novel antifilarial lead molecules.
Hence, our finding about the dysregulation of miR-325 in preterm infants, despite the limited significance level due to small sample size, provides a useful clue for the development of biomarker for periventricular leukomalacia that may lead to its prevention or treatment.
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This information can give new key clues for the development of more actual physical models.
The results obtained provide important clues for the development of carriers for the sustainable delivery of bioactive compounds.
The inference of the protein complex composition and of its molecular details can also provide relevant clues for the development and the design of drugs.
This new information about the immunotoxic roles of DIM in a newborn mouse model may provide valuable clues for the development of a safe supplement, especially one designed for human infants.
The M4/M2 relative selectivities of some of our compounds are similar to the better hexahydrosiladifenidol derivatives, and may provide some important structural clues for the development of potent and selective M4 antagonists.
Genetically modified mice provide models for Alport syndrome evolving to renal failure that have resulted in clinical recommendations, polycystic kidney disease models that have provided clues for the development of tolvaptan, that was recently approved for the human disease in Japan; and animal models also contributed to target C5 with eculizumab in hemolytic uremic syndrome.
The present data suggest that using endophenotypes (here, heart rate) and evaluating interactions of genetic and environmental factors (here, anxiety) provides a valuable way to investigate and understand the complexities of pathophysiological mechanisms that may underlie components of hypertension, and may provide clues for the development of improved treatments for this complex disorder.
These data might provide important clues for the development of specific small molecule HDAC inhibitors.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com