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Nucleosomes did not appear to correlate with any of the clotting tests or variables predictive for disease severity or patient outcome.
In addition, the cytotoxicity results revealed that the electrospun PCL MWCNTs nanofiber membranes possessed good in vitro biocompatibility, and hemolysis and kinetic clotting tests indicated that the PCL nanofiber membranes did not enhance blood coagulation after the addition of MWCNTs.
The model was adjusted to accurately represent both preclinical information, such as directly measured dissociation constants, and clinical measurements such as the common clotting tests, prothrombin time (PT) and activated partial thromboplastin time (aPTT).
Rather than reproducing known standard clinical measurements, such as the prothrombin time and activated partial thromboplastin time clotting tests, the anticoagulant benchmarking was based on a simulation of physiologically plausible clotting scenarios.
Multiple laboratory data including clotting tests and fibrinogen levels were also recorded.
The 2 types of ON showed different alterations in the clotting tests.
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Dr. Holcomb, in Houston, said his hospital, the only one he knew that was now using it, gives it only to patients whose blood fails a clotting test.
The blood compatibility of the TiC0.3N0.7 coating was evaluated by haemolysis ratios, dynamic blood clotting test, plasma recalcification time and platelet adhesion.
Then the corrosion resistance in phosphate buffered saline (PBS) and the hemocompatibility of the coating were further evaluated by potentiodynamic polarization, blood clotting test and platelet adhesion test.
The blood clotting test and the platelet adhesion test results indicated that the TaCxN1 − x coatings deposited at Ts of 25 °C and 200 °C possessed better hemocompatibility than the coating deposited at Ts of 400 °C.
Protein C activity was determined with a clotting test (HemosIL ProClot APTT-SP, Instrumentation Laboratory) based on the prolongation of APTT in the presence of activated protein C, generated by an activator derived from snake venom.
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