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As a result, current guidelines recommend that all human bite victims receive antibiotics and that wound closure is delayed until the area can be properly debrided and washed".
If the pituitary gland functions normally, producing appropriate amounts of growth hormone, while epiphyseal closure is delayed, the growth period of the bones will be prolonged.
Conversely, in transgenic mice overexpressing the antagonist follistatin, skin wound closure is delayed and scar formation reduced [44].
We compared wound closure in untreated and SST-treated wound models 48 h post-wounding and observed that epidermal wound closure is delayed in SST-treated models (Fig. 8A).
This may be because they are prematurely apoptotic or instead that they are undergoing apoptosis at an "appropriate" time, but germ band retraction and dorsal closure is delayed.
In addition to open spina bifida, we analysed the frequency of tail flexion defects, which arise when neural tube closure is delayed, and straight tails, which occur among embryos in which spinal neurulation is apparently normal.
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But as a mother whose son, Andrew, was murdered in Mississippi 37 years ago, even the glimmer of closure was delayed when she saw the obituary of Cecil R. Price, the deputy sheriff who delivered Andrew to his killers.
We found that the wound closure was delayed in the periostin−/− mice coupled with a delay in re-epithelialization and with reduced proliferation of keratinocytes.
These results demonstrate that the wound closure was delayed in periostin−/− mice, which would have been caused by defective re-epithelialization and granulation tissue formation.
To demonstrate the role of periostin in vivo, we employed an experimental wound healing model using WT and periostin−/− mice, and found that the wound closure was delayed in the periostin−/− mice.
The duration of the outbreaks was longer in the closure group where closure was delayed to seven or more days.
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