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At closing of the study, the median follow-up of the patients was 34 months (range 6 122 months).
Results of a follow-up questionnaire 1 year after the closing of the study were used as a secondary outcome to describe the long-term results.
In phase I and II combination trials, SU5416 could be given safely in combination with 5-FU and leucovorin, but combining SU5416 with cisplatinum and gemcitabine yielded an unexpectedly high number of severe thromboembolic complications, leading to premature closing of the study (Kuenen et al, 2002a).
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At the close of the study, which followed 4,000 women for as long as six years, 32percentt of the old-style welfare group were married, but only 24percentt of the welfare applicants assigned to Iowa's new program, a mix of work requirements, sanctions and incentives typical of many states' new welfare programs.
Morphine doses that were initially 35% climbed to 62% at the close of the study.
Concentrations declined to 4 mg N L-1 at the close of the study, 24 months after treatment.
By the close of the study, antiplatelet therapy was used by half the patients.
Analysis of quantitative data will be performed at the close of the study.
Seventy-nine patients were still under review at the close of the study.
After the close of the study the mammograms were requested from the study centres and from other hospitals which provided routine mammography to study participants (23 hospitals).
Survival status was determined as of the close of the study on 30 June 2000 with a median follow up of 5.6 years.
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