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Measurements took place after admission starting with the closest time point of the regular sampling period of 01 00, 07:00, 13:00 and 19 00 hours with a precision of ± 10 min. for 4 days.
Time-variant covariates were matched to a retinal event that occurred at the closest time point.
When the primary outcome was appraised at a single time point, we recorded the SF-36 outcomes at the single same (or closest) time point.
Where trials reported more than one follow-up time point, data were extracted from the closest time point to 6 months for depression trials and 12 months for schizophrenia trials.
Mean scores represent changes between the 90-day and the baseline values for all-survivors (those in hospital 90 days from study enrollment, or closest time point to 90 days [last observation carried forward analysis; see text]).
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Glucose half-life in the gastrointestinal tract was individually determined by linear curve interpolation of relative glucose retention during the OGTT by using the closest time points to cross the 50% threshold (5).
Glucose half-life (T1/2) in the gastrointestinal tract (i.e., time until half of the total glucose had been absorbed from the gut) was individually determined by linear curve interpolation of the relative glucose retention during the OGTT by the closest time points to cross the 50% threshold (24).
To identify coordinated and significant changes between the two chronologically closest time points from each strain, the collapsed gene lists (21,673 genes) were ranked based on the observed relative difference upon performing significance analysis of microarrays (SAM) in J-Express 2009.
The respective pharmacokinetic variables were calculated from the adjusted data as follows: Cmax and tCmax were reported from the observed adjusted maximum values, the early and late tCmax50% were calculated by linear interpolation between the two closest time points, and the AUC values were calculated using the linear trapezoidal rule.
Far too many mice would be required to obtain enough statistically significant data from close time points.
Keeping in view of the transient dynamics of the circuits, Fluorescence Activated Cell Sorter (FACS) measurements were taken at closer time points initially, and then at longer intervals.
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