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The catalytic center includes a mobile ″lid″ loop which when open (structure PDB 2qew, Figure 5a) allows substrate/product binding or release, but closes (structure PDB 2qf2, Figure 5b) over these ligands when they are bound during catalysis [ 30- 32].
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Superposition of the DraIII closed structure to Hpy99I, PacI and T4 Endo VII shows the high structural conservation of the HNH active site (Fig. 4).
Third, the 1D closed structure would greatly facilitate the inference process for online ATR tasks.
These factors work together to modify the microstructure producing homogeneous compact closed structure.
The undulators have a new design of a Bx and Bz closed structure for insertion vacuum chamber.
Numerical determination and variation of tortuosity by closing structure windows provided a possibility to match the pressure drop calculated in modelled structures with experimental literature data.
In contrast, in the GTP bound state, TG2 exists in a compact and closed structure that decreases the accessibility of the active site [8], [9].
2OWT represents the holo (closed) structure, and its ligands, CO32– and iron, were removed before docking.
In Es. coli DHFR, this Met20 loop was identified in crystal structures to form an open, occluded, and closed structure.
Conversely, the E. coli clamp forms an extremely tight, closed structure in isolation [ 10, 37, 86] and has a long lifetime on DNA (t1/2 ~ 1 h) [ 85].
Structurally, porphyrin consists of four pyrrole rings (five-membered closed structures containing one nitrogen and four carbon atoms) linked to each other by methine groups (−CH=).
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