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20 There is a recognised need for instruments or tools that can be used by regulatory agencies to identify individuals who may be at higher risk of having brain injury from cumulative head trauma and require closer safety surveillance.
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Closing safety holes requires that "the safety inspector/auditor of research laboratories directly report to an identified individual/office with organizational authority to implement safety improvements," the report concludes.
To allow close safety monitoring, all patients were hospitalized during the first treatment cycle or until the investigator considered it appropriate to manage the patient on an outpatient basis.
During the treatment period, subjects were hospitalized in the PAREXEL Early Phase Clinical Unit (Berlin, Germany) from 1 day before the study drug administration until 3 days after administration for serial PK sampling and close safety monitoring.
In view of the possibility of a monacolin interaction with antiviral agents through a cytochrome P450 mechanism, such a study with close safety monitoring may be warranted in the search for additional lipid-lowering agents compatible with HIV therapies.
Birmingham and Huddersfield drew 1-1 at St Andrew's, both sides moving closer to safety.
AFC Wimbledon continue to edge closer to safety – their 2-0 victoverover Morecambe was their fourth win in five.
WBA edge closer to safety.
The result moves Mayo edged closer to safety.
Leroy Lita's equaliser against Ipswich nudged Sheffield Wednesday a step closer to safety with two games left.
"This result gets us closer to safety, we have seven games left and our recent form is good.
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CEO of Professional Science Editing for Scientists @ prosciediting.com