Family functioning was assessed by asking caregivers to rate family conflict, communication, and closeness as average, above average (high), or below average (low); families were considered at risk if they endorsed high levels of conflict or low levels of communication or closeness between family members.
Therefore, it represents high and closeness of average parameters to the standards and shows the risk limit of river water.
The average closeness (Clo) score was calculated by the sum of different closeness scores (Clo i ) divided by the total number of nodes analyzed (N v )): (3) Clo = ∑ i Cl o i N (v ).
Although our proposed technique integrates networks and estimates the average closeness centrality, the performance will not be as good as the average closeness centrality computed from the actual graph G.
Different from the average closeness centrality which we used as a measurement in Figure 4, the error function accumulates the closeness centrality difference for each individual node, so that the offset effect of average closeness will not occur.
As a result, when we consider the average closeness centrality, the differences may be offset by each other.
In terms of average closeness centrality, increasing or decreasing the percentage of insensitive nodes in network did not make substantial impact to the performance of our purposed technique.
One plausible explanation is that: the average closeness centrality used in this experiment only reflects the performance of our approach in an abstract level.
In Figure 4, the blue line represents the average closeness centrality computed from G, which is a gold standard, so that the closer to this blue line the better it is.
Closeness measures the average distance a node has to all others in the network – shorter values mean greater ease of interaction with all others.
As a step toward drugCIPHER, we investigated the relations between drug similarities in the pharmacological space and drug genomic relatedness (GR) in the genomic space, where GR is defined as the average closeness of drug targets in the PPI network (See Materials and Methods).
