Sentence examples for closely recapitulating from inspiring English sources
Furthermore, RWV organoids at day 25 (D25) reveal similar maturation and transcriptome profile as those at D32 in static culture, closely recapitulating spatiotemporal development of postnatal day 6 mouse retina in vivo.
This PDAC microtissue, closely recapitulating key PDAC microenvironment characteristics, provides a valuable tool to elucidate the complex stroma cancer interrelationship and could be used in a future perspective as a testing platform for anticancer drugs in tissue-on-chip technology.
Extensive genetic analyses, recently using high-throughput molecular techniques and next-generation sequencing methodologies, and the development of sophisticated genetically engineered mouse models closely recapitulating human disease, have improved our understanding of the genetic basis of pancreatic neoplasms.
Our findings demonstrate that the key aspects of human carcinogenesis closely recapitulating the features of the native tumors can be faithfully reproduced in vitro when an appropriate oncogene is used to transform its natural target cells; this in turn points to the fundamental role in malignant cell transformation of potent oncogenes expressed in the relevant target cells.
Activation of most target genes was not sustained in the older cohort, thereby closely recapitulating the biochemical studies.
We conclude from these experiments that Par1b is required for TGF β responses in vivo, closely recapitulating the requirements of Dvl in this pathway.
Organoids closely recapitulate several properties of the original tumor.
For the most part, the rodent liver closely recapitulates human structure and function.
Patient-derived xenograft (PDX) tumor models have been shown to closely recapitulate human tumor biology and predict patient drug response.
The complexity of CFTR maturation and turnover requires the use of cellular models that closely recapitulate the specific properties of the clinically most affected organs.
Thus by targeting multiple cancer associated human mutations to the appropriate murine epithelia, mice develop tumours that more closely recapitulate the human disease.
