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Normal healing can occur only if the wound edges are clean and can be closely opposed without undue stress on the tissue.
We have designed an assay to determine whether a closely opposed lesion causes an increase in adenine insertion opposite an 8-oxodG in bacteria.
This enhancement of mutation frequency supports the in vitro MDS studies, which demonstrated the inability of base excision repair to completely repair closely opposed lesions.
In pneumoperitoneum, free abdominal air produces a sonographic appearance of linear enhancement of peritoneal stripe with reverberation artifacts (Fig. 2a; Additional file 1), and the high differences in acoustic impedance between closely opposed air and fluid produce ring down artifacts starting from peritoneal line (Fig. 2b; Additional file 2).
These tumors had distinct, closely opposed borders consistent with expansile growth of both tumors.
Cells with identical ultrastructural attributes were observed on the surface as well as just within the explant tissue (Figure 2b), and frequently were found to be closely opposed to fibroblast at the edge of the explants (Figure 2c).
Similar(34)
As a result, the voters who say they are following news about the Republican bill most closely oppose it by a two-to-one margin (33percentt favor, 67percentt oppose).
DSBs can be formed indirectly by two closely opposing single-strand breaks.
On the other hand, UV lesion formation has a strong sequence bias, and actual measurements on irradiated DNA proved that approximately 1% of all UV-induced lesions are configured as closely opposing lesions [76 78].
One instance where this might happen is when two UV lesions, one on each DNA strand, are generated in a limited region; this configuration has been defined "closely opposing UV lesions" [73 75].
However, its association appeared to be so strong that it failed to dissociate over this concentration range, presumably because it lacked the electrostatic repulsive interactions between closely opposing Lys side chains seen in 1.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com