Ordinarily, TED's closely governed editorial process begins with the concept: the conference's "curators" feel out a speaker's interests, looking for material that's new and counterintuitive.
Throughout the 19th century, Java was the most intensively developed and closely governed of all the islands of the Dutch East Indies, and it quite naturally became the focus of Indonesian nationalism in the early 20th century.
(David Linden, "The Compass of Pleasure") That would be the "medial forebrain pleasure circuit," which, according to Linden, inspires much of human behavior and is "the anatomical region most closely governed by laws, religious prohibitions, and social mores".
The model is based on experimental work found from extensive literature research, and methods in the model are closely governed by biological mechanisms.
Given that Spry2 antagonism of the FGF-10 receptor, FGFR2b, is believed to be an important regulator of airway branching periodicity, it follows that mTORC1 activity and its regulation of HIF-1α should be closely governed by Spry2.
