The ANS-fluorescence is used to monitor the changes in solvent-exposed hydrophobic surface: ANS binds to spatially close solvent-exposed hydrophobic patches [51], shifting the fluorescence maxima from 520 (isolated ANS) to 480 nm (ANS-bound to a polypeptide hydrophobic patch).
The structure of NPC1L1 NTD), while sharing the same overall topology as NPC1 NTD), reveals a cholesterol binding pocket that is closed from solvent, suggesting a gating mechanism that relies on the movement of multiple elements around the cholesterol entrance.
Depth index (DI): the depth of an atom i (DPXi) can be defined as the distance between atom i and the closest solvent accessible atom j.
He cites the recent proposal by Brandeis University to close its solvent art museum and sell off the collection to pay the university's expenses.
Solvents were purified with a VAC closed loop recirculation module solvent filtration/purification system.
Binding of PKI5 24 increases the compactness of the enzyme as it adopts a closed, solvent-protected conformation, with 54 of 231 resonances displaying φ values around 0.3, including residues in β-strands 2 and 3, the C-helix, the αC−β4 loop, hinge, αD, αE, the segment from the P+1 loop to the F-helix, αF, αH, and the αH−αI loop.
In April, the troubled Peninsula Hospital Center closed, unable to stay solvent after its lab failed a state exam and was shut down by the New York State Health Department, which said the lab was dangerous for patients.
By using a thermodynamic state function which is suitable for a partially open system, open with respect to solvent and closed with respect to solute atoms, a generalized Gibbs adsorption isotherm can be derived.
Results indicate that small steric volumes in the hydrophobic region, electron-withdrawing groups next to the aryl linker region, and atoms close to the solvent accessible region increase the Src inhibitory activity of the compounds.
Transfer of analytes to the GC column is accomplished by rapid heating of the injector port after the solvent vent is closed.
