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Software ecosystems is an emerging trend within the software industry, implying a shift from closed organizations and processes towards open structures, where actors external to the software development organization are becoming increasingly involved in development.
As mentioned earlier, the difference in ICIT scores is due to three effects related to perennial, added and closed organizations.
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"When I took over it was a closed organization," he says.
Many Catholics have felt for a long time that the church is a closed organization run by a select group committed to secrecy, which has often done great harm to the church.
In human, the nucleosome landscape at the promoter region has a bimodal distribution, with a relatively open organization for expressed genes and a relatively closed organization for silent genes (Additional file 1: Figure S12).
Marie Stopes Kenya is a nongovernmental organization, however, and a "closed system" delivering family planning via fixed sites and mobile services (in private-public partnership with the Ministry of Health).
As shown before, vitro+/vivo+ promoters have similar closed nucleosome organizations both in vivo and in vitro (see Additional file 6).
Furthermore, we identified four promoter classes characterized by distinct regulatory modes of nucleosome positioning: DNA-encoded open nucleosome organization, nucleosome eviction, the cooperativity between nucleosome sliding and histone acetylation, and non-DNA-driven closed nucleosome organization.
Their closed nucleosome organization encoded in DNA seems to protect these cryptic sites.
We speculated that the DNA-encoded closed nucleosome organization protects unbound motifs at vitro+/vivo+ promoters.
Other factors override the underlying DNA sequence to form the closed nucleosome organization at vitro-/vivo+ promoters.
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