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The fact that biological tissues are stable over prolonged periods of time while individual receptor-ligand bonds only have limited lifetime underscores the critical importance of cooperative behaviors of multiple molecular bonds, in particular the competition between the rate of rupture of closed bonds (death rate) and the rate of rebinding of open bonds (birth rate) in a bond cluster.
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A $77 million Marriott is rising at the site of Adriaen's Landing, a huge development that is intended to lead a renaissance downtown; a new Holiday Inn Express has opened in place of the former Ramada Inn; the downtown Hilton is undergoing an extensive renovation; and a New York developer is remaking the closed Bond Hotel into an extended-stay Homewood Suites.
In the first case, the magnetic field freezing-in is caused by circular induction currents, compensating variations of the magnetic flux through a closed contour bonded to the moving medium.
In our models, however, the switch loops mainly serve to anchor the lower half of the nucleotide cleft in place against the microtubule surface (via the closed hydrogen bond network, anchored by the N255 linchpin residue), while seesaw-like motion by the upper half of the nucleotide cleft (composed of the N-terminal subdomain) translates the P-loop down towards the switch loops.
The lesson for investors is to evaluate closed-end bond holdings closely.
Investors put almost $14 billion into closed-end bond funds in the first six months of 2003 alone, accounting for nearly 10percentt of their overall bond assets.
That has made it difficult for some closed-end bond funds to maintain their dividends.
"Income-ratio analysis has proven highly insightful in predicting dividend increases or reductions in closed-end bond funds," he said.
His recent study of closed-end bond funds found that, among 20 variables, income ratios were the best gauge of dividend stability.
The average discount in closed-end bond funds expanded from 0.2 percent at the end of 2012 to 5.9 percent nine months later, Morningstar's data show.
"There are many closed-end bond funds and mortgage funds that were just annihilated in May," said Anthony Baruffi, a senior portfolio manager at SNW Asset Management in Seattle, which specializes in fixed-income assets.
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