Rather, the close, probing, examination of a process alone cannot account for causation.
The presence of clusters of "close" probes provides both insights into probe performance behaviour and a sanity check on the distance measure itself.
If the closest probe for a gene was found at a distance further than 10 Kb, the gene was no longer considered.
Then, for every target blob, the closest probe blob was found, the deviations ΔxΔy were calculated for all such probe-target pairs, and plotted as a 2D histogram ('the co-localization plot').
More precise clocks could also enable a closer probing of Einstein's theory of general relativity, which dictates that time flows more slowly under the pull of gravity.
In practice due to computation constraints, we only consider the 400 closest probes from bin i (200 probes upstream and 200 probes downstream) for smoothing which already give a close approximation to the full Gaussian smoother.
If a gene has low expression and is measured close to probe's background level, it may show little change in expression value after actinomycin D treatment, which can be erroneously viewed as evidence of high mRNA stability.
Since detection of the transcript usually is better the closer a probe sets is relative to the 3' end, many of the extended probe sets provide better markers for gene expression.
Points (8– 10) outside the common ancestor 4 of the probes 11 and 14 lie on the diagonal line A. Point 12, closest to probe 11, is located on line B, and point 13, closest to probe 14, is located on line C. Points 8 and 9 have been degenerated into the position of node 2. The degeneracy can be resolved using other triplets of probes.
The closer the probe is to the target, the more electricity flows.
