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One explanation for the conservation of genomic organization is that the proper regulation of these genes may depend upon their close physical linkage (reviewed in [18].
Given their close physical linkage, recombination between gnd and cps is probably unfrequent, and gnd sequencing could therefore be used as a proxy for K typing, which is technically demanding [50], [65], [66].
Finally, the significantly higher proportion of private alleles at exon 2 amino acid sequences compared with non-coding intron 1, provides strong additional evidence that despite close physical linkage between intron and exon sequences, divergent selection contributed to the shaping of the functional allelic composition of the species.
Because of this close physical linkage, allelic variants in these genes very likely cosegregated.
We wonder if interaction retention between Hox genes might be more important than merely close physical linkage of them.
Since ITS-1 and ITS-2 have a close physical linkage, both phylogenies are expected to reflect the same evolutionary histories.
Similar(37)
Close genetic and physical linkage between the murine haemopoietic growth factor genes GM-CSF and Multi-CSF (IL3).
This was the prerequisite to close physical gaps between linkage groups depicted in the comprehensive second generation map [ 21] as well as the gap between PPARGC1A and IBSP in the SUNbRH map [ 6].
Loci can be overlapping but this may be because of linkage (ie, close physical proximity between loci) rather than direct pleiotropy from a single causal loci.
At this point, we have no explanation for the observation, but it implies that tef-1 is involved in sexual development in Neurospora, or that it is affected by genetic linkage through a close physical proximity to the mat locus [ 31].
The second significant SNP is in linkage disequilibrium with the Ser SNPs (although it is not in close physical proximity to Ser ) and is located in regulatory elements of the Furin 1 gene.
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