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The predicted proteome of a given parasite was broken down into overlapping fragments, each of which was screened for close hits in the human proteome.
In real datasets however, there are sometimes sporadic close hits with low bit scores (Additional file 1 : Figure S1D).
Occasional gene loss events may take away some of the expected number of close hits (Additional file 1 : Figure S1E).
This is because there are more close hits to be found in Uniprot which are quicker to align.
Blasting the whole NCBI database only yielded four close hits, with highest AAI (73%) with Anaeromyxobacter dehalogenans 2CP-1.
Furthermore, these servers are well known to miss structural similarities and it is not clear to us therefore what the absence of close hits would signify.
Similar(49)
"I hit it close, hit a lot of fairways and rolled in some nice putts".
The news that the Catholic schools would close "hit me like a Mack truck," she said.
Torquay improved after the break and Jake Robinson came close, hitting the bar from 20 yards.
The death of Heman, with whom Allen had been quite close, hit him quite hard.
The "Feel So Close" hit-maker wears nearly-"Sweet Nothing" in a new underwear shoot for Emporio Armani.
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