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These shell structures are a close analog to shell structures observed for metal clusters [14, 15].
The X-ray co-crystal structure of EGFR with a close analog (17) was determined and validated our design rationale.
Ligand 2 shows high inhibitory activity, while the compound 3, a close analog of 2 with the cyclopropylamide replaced by tert-butylamide, exhibits drastically diminished potency.
This guided the design of a close analog showing micromolar inhibition of two human pathogenic NAD kinases and potent bactericidal activity against Staphylococcus aureus in vitro.
(Since this problem is a close analog of the 'paradox of tragedy', some of the references below are to literature not explicitly about music, but the transposition of the arguments to music is not difficult to imagine).
A close analog of this situation exists when the liquid is in forced flow, and the heat flux from the vertical rods is quenched by forced convection boiling of the upward liquid water flux.
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Hume's worries about consent theorists' interpreting residence in a territory as consent to its government have close analogs in this kind of context (Hume, 1748, p. 263).
We will present studies where reaction driven de novo design software simulations are used to "re-invent" know drug molecules or close analogs.
We also developed MS4748 (7) and MS4740 (8), very close analogs of 5 and 6 respectively, which are incapable to degrade the ALK fusion proteins, as negative controls.
We here discuss the design, synthesis and evaluation of LIMK inhibitors based on a pyrrolopyrimidine scaffold, which represent close analogs of LX-7101.
For this study, a refined form of the modern analog technique was developed, called the hierarchical analog technique, which can constrain paleoenvironmental properties even for fossil-pollen assemblages without close analogs in the modern-pollen record.
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CEO of Professional Science Editing for Scientists @ prosciediting.com