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Here, the loci were demethylated, but the selection of drug-resistant, ZEB1-expressing clones induced a complete methylation and a reduction in active histone marks.
More virulent malaria clones induced a greater plasma TNF-α response relative to their less virulent counterparts, even when any linear and (in this case non-significant) quadratic effects of asexual parasite load were statistically controlled for (Long et al. 2006).
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To test whether competitive interactions were involved in the elimination of lgl-/ cells from the normal tissue, we performed a double clonal assay in which lgl-/ clones were induced in an lgl+/- background in parallel to wild-type clones induced in a wild-type background.
The activity of the dmyc promoter is indeed increased in lgl- clones induced in a Minute background and in follicular cells.
In lgl- clones induced in a wild-type context, where lgl mutant cells do not lose polarity, dmyc transcription is not altered.
GFP-expressing clones induced by regimens A-H; arrows point to DT/DB junction.
GFP-expressing clones induced by regimens A-H; arrows point to DT/TC junction.
A library of SE clones induced during gastrulation and referred to as the lox-LacZ library has been produced using 4-OHT concentrations yielding labelling frequencies between 1 and 2×10−1 (Table 3).
In the ovary, ∆let-7 clones induced specifically in somatic ECs result in a peculiar germarium architecture where both the germline and soma are abnormal.
To examine how the pool of founder cells produces the SE, we generated a lox-LacZ library of clones induced at E6.5 in [CT2×R26R] F1 embryos.
Besides the nine different TG-resistant clones described in this paper, we examined an additional fifteen TG-resistant clones induced by Dox treatment.
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