4, 5 Concerning T cells, only two studies reported that particular CD8 clones identified in brain biopsies could also be found in CSF and blood several years later in two patients.
aSP-f and aSP-g tra clones were morphologically indistinguishable from wild-type male clones, even when aSP-f or aSP-g were the only tra-deficient fru+ clones in the brain.
Moreover, although we have recovered the otd -/- LALv1 lineage along with other neuroblast clones of the antennal lobe including the ALv1 lineage, we frequently recover it with no other clones in the brain.
In the wild type we recovered 34 single cell clones in 131 brains examined (clonal frequency ∼26%); in otd mutant clones we recovered only 40 single cell clones out of 310 brains examined (clonal frequency ∼13%).
Propagation of the three types of clone in mouse brain resulted in swa-resistant 22L prions (Fig 1Ai).
In addition, cas is known to be involved in post-embryonic brain development as small homozygous somatic mutant cas clones in the adult brain lead to ellipsoid body and mushroom body defects [ 65].
Clones pMP-e and aSP-a are the most dimorphic fru+ clones in the central brain; their male-specific arbors occupy 6.5% and 2.7% of the central brain neuropil, respectively.
In accordance with previous reports [22] [24], we found that most prosv17 mutant clones in the larval brain were significantly larger than control wt clones (Fig. 4.A C).
Thus, FEZ1 interactions are relatively enriched in clones from the brain, while FEZ2 interactions are of more ubiquitous origin.
This novel isoform was found as one clone out of 64 in brain; it has not been detected so far in human transcripts and it may be a low abundance transcript that is specific to the mouse/rat evolutionary branch.
To more precisely characterize the effect of pros LoF at the cellular level, we generated null-mutant MARCM NB clones in the developing postembryonic brain using prosv17.
