These data indicated that different Foxn1Δ/Δ T cell clones have different responses to the same antigen in vivo.
As the HLA class II molecules presenting the hTERT epitope to the T-cell clones were different (−DQ, −DR, and −DP) and the three clones have different fine-specificity (results not shown), these results strongly suggest that natural processing of hTERT may give rise to many different peptide fragments, fitting into multiple HLA class II molecules.
However the ST-8 and ST-10 clones had different serogroups.
The tallest clones had different ploidy levels and geographic range (A133AU10X, E624RO8x, A205RU4x, A120JP8x, E656RO6x and E625RO6x) and the shortest clone was a European octoploid (E666CZ8x) (Table 3).
On the other hand, utility of analysis of secondary mutations is very challenging because imatinib-resistant GISTs are very heterogeneous with multiple clones having different secondary mutations within the same or different nodules [ 28- 30].
As expected, each clone had different characteristics regarding the expression of red fluorescent protein before and after induction.
Using three isogenic clones that have different drug resistance profiles corresponding to unique mutations in the pfcrt gene (106/1K76, 106/176I, and 106/76I-352K), we investigated changes in gene expression in these parasites grown with and without CQ.
We posit that Alteromonas populations and actually most, if not all, prokaryotes live in complex consortia of multiple clones that have different gene complements, increasing the activities and environmental ranges in which the population can be successful [ 61, 62].
Collectively, it may be important to find technology to select and/or increase iPS cell clones that can generate melanocytes with high yield, as each iPS cell clone may have different differentiation potency.
A single clone could have different genetic structures at the origin of the blaOXA-23 acquisition.
In spite of the very general term "stem cell," this population of cells is far from homogeneous, and different BMSCs clones have greatly different phenotypic properties and, therefore, potentially different therapeutic potential.
