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The results indicate that some clones are sensitive to BEZ235 whereas other clones are insensitive.
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STAT1H clones were resistant to all treatments while STAT1L clones were sensitive.
A total of 16 HAT resistant clones were sensitive to both puromycin and neomycin, indicating that the targeting was in cis and Cre-mediated recombination between loxP sites occurred as described previously [36].
It is noteworthy that all HNSCC clones were sensitive to PI3KI at high doses.
The EST approach provides only partial sequences of individual cDNA clones, is sensitive to cloning biases, and is associated with high costs and difficulties in data analysis.
Four of 15 Spc-resistant Tg-110CISP clones and six of 15 Spc-resistant Tg-220CISP clones were sensitive to Nm.
All 100 KmR clones were sensitive to ampicillin (500 μg/mL), thereby indicating that the insertion of the minitransposon carried by pBAM1 occurred as expected.
All the clones showed resistance to TRAIL-induced apoptosis, as illustrated in Figure 2e for clone 4. However, all clones were sensitive to anoikis, as illustrated in Figure 2f for clone 4, ruling out the extrinsic pathway.
The PfEMP1 of both B6 and C7 Fclonesvap1Δ clones were sensitive to trypsin digestion in a manner comparable with FCR3 as judged by the appearance of a shortened intracellular PfEMP1 fragment in Western blot analysis (Fig. 6).
Upon constraining our model to the physiological regime relevant to the experiments, we find that the calculated shapes of the clone size distributions are sensitive to effectively only two composite parameters.
This is consistent with the findings that larvae with randomly induced PI3K overexpression clones are starvation sensitive (Britton et al., 2002).
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