Sentence examples for clonal variability from inspiring English sources

In addition, as shown by the same study, clonal variability of immortalized fibroblast lines may lead to variable gene expression irrespective of either APP-/ or APP+/+ genotype [ 16].

We confirmed that all control and FUS lines were phenotypically similar, thereby excluding clonal variability (Supplementary Figs. 2 9).

However, challenging clonal variability, limited vector repertoire and insufficient genome annotation have hampered further developments.

The clonal variability was systematically investigated and strategies formulated to circumvent untargeted events, thereby streamlining the screening procedure.

Although progress has been made using adult mesenchymal stem cells, these cells suffer from limited accessibility, senesce upon expansion, and clonal variability.

Whilst progress has been made using adult mesenchymal stem cells, these cells suffer from limited accessibility, senescence upon expansion and clonal variability.

With increasing sub-clonal variability, the risk that individual cells overcome selective barriers (i.e. growth inhibition) and progress towards malignancy increases.

Second, the expression and size of several surface proteins, such as the Vpma family, can show rapid and random fluctuations, thereby generating multiple antigenic surface configurations and broad intra-clonal variability [ 24].

Figure 2 clearly shows that although there is considerable interindividual variability, clonal expansions occur at day 7 and to a greater extent in switched isotypes than in IGHM.

Because we maintain our cultures as clonal lineages, intraspecific variability in life span and fecundity can be attributed to environmental influences and maternal effects.

We combined single-cell measures and a mathematical model to investigate the mechanisms generating variability in clonal populations of virally infected bacteria growing in a homogeneous environment.