Sentence examples for clonal reduction from inspiring English sources

Thus the use of FLAG-Ida induction in Pgp-positive cases induces a slight shift in initial efficacy, such that efficient clonal reduction results in improved CR for this subgroup, but these patients have an increased frequency of relapse with a consequent lack of effect on OS.

Importantly, continuous Rac1 inhibition in holoclones results in clonal conversion and reduction of growth potential.

Importantly, continuous Rac1 inhibition in keratinocyte stem cells results in clonal conversion and reduction of growth potential.

Due to clonal variation, the reduction of Daphnia magna quite varied after stressor exposure like cadmium or cyanobacteria Microcystis aeruginosa [ 39].

Such an extreme reduction of clonal diversity due to long-term clonal erosion may have profound impacts on the microevolutionary potential of such populations.

The number of colonies derived from either PAPST1- or PAPST2-KD cells that remained in an undifferentiated state fell to approximately 60% of the number from control cells even in the presence of LIF and serum in clonal density culture, showing reduction of self-renewal in PAPST-KD cells (Figure 3A).

Firstly, we noticed a marked reduction in clonal frequencies of the wild-type and otd null single cell clones.

Genomic analysis appeared to show a reduction of clonal diversity following treatment with selection of some clones with simpler copy number profiles.

Similarly, a recent laboratory study revealed significant selection in initially multiclonal populations in response to low pH after 160 days, with the lowest pH leading to the most dramatic reduction in clonal diversity (Lohbeck et al. 2012a).

Each mature GC is generally derived from one to three B-cell clones, which manage to survive a significant reduction in clonal diversity and then go on to endure V(D J hypermutation.

A reduction of clonal diversity over time has also been observed in natural populations of rotifers (e.g., [ 11]), aphids (e.g., [ 12]), as well as plants (e.g., [ 13]).