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In the model, immune operators including clonal proliferation, hypermutation and immune suppression are designed to proliferate superior antibodies and suppress the inferiors.
Langerhans-cell histiocytosis is a rare disease involving clonal proliferation of Langerhans cells [1, 2].
LCH is caused by clonal proliferation of activated dendritic cells and macrophages [20].
Myeloproliferative neoplasms (MPN) are a group of disorders defined by clonal proliferation of mature myeloid cells with overlapping clinical features.
Cutaneous T-cell lymphomas (CTCLs) are non-Hodgkin's lymphomas characterized by the clonal proliferation of skin-invasive mature T lymphocytes.
Multiple myeloma (MM) is an incurable malignancy in majority of patients characterized by clonal proliferation of plasma cells.
The antibody network model as well as the evolution process including clonal proliferation, immune elimination, and immune memory is studied.
Multiple myeloma (MM) is a plasma cell dyscrasia characterized by the presence of a clonal proliferation of tumor cells.
Immunohistochemically, plasma cells in the interfollicular region were evenly positive for kappa and lambda light chain, which meant no evidence of clonal proliferation.
Eosinophilic granuloma is a rare, benign tumor-like disorder characterized by clonal proliferation of antigen-presenting mononuclear cells of dendritic origin known as Langerhans cells [1, 2].
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematological malignancy characterized by the clonal proliferation of pDC-like cells (Facchetti et al., 2008).
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