Sentence examples for clonal instability from inspiring English sources

Interestingly, the inability to form C/L/A translocations if all three genes are located on three different chromosomes and the observation of clonal instability point to the following two sources for C/L/A translocations.

Because of the clonal instability of the PC12 cell line (Fujita et al. 1989), the experiments were performed on cells that had undergone fewer than five passages.

Because of the clonal instability of the PC12 cell line (Fujita et al. 1989), we performed the experiments on cells that had undergone fewer than five passages.

Because of the clonal instability of the PC12 cell line (Fujita et al. 1989), we performed experiments on cells that had undergone fewer than five passages.

Because of the clonal instability of the PC12 cell line (Fujita et al. 1989), the experiments were performed on cells that had undergone fewer than five passages, and all studies were repeated several times with different batches of cells.

Because of the clonal instability of the PC12 cell line (Fujita et al. 1989), the experiments were performed on cells that had undergone fewer than five passages, and all experiments were repeated with multiple batches of cells.

These events promote genomic instability, clonal expansion and the development of skin cancer.

Thus, although most cells within a tumor are thought to have a clonal origin, genomic instability and the dynamic nature of selective pressure can lead to multiple routes of genetic diversification within the adaptive landscapes of tissue ecosystems [ 15], and can ultimately result in a genetically, epigenetically and phenotypically diversified tumor.

Finally, differentiating between clonal and subclonal instabilities will facilitate a better understanding of the life histories of tumors, because they show extreme intra-tumor heterogeneity [ 54– 54].

Talamo A, Chalandon Y, Marazzi A, Jotterand M. Clonal heterogeneity and chromosomal instability at disease presentation in high hyperdiploid acute lymphoblastic leukemia.

CGH analysis of a biphasic malignant meningioma confirmed that the disparate histologic components were genetically related and likely derivative from a common precursor, demonstrating genetic instability and clonal expansion.