Sentence examples for clonal fluctuation from inspiring English sources

New approaches to unbiased and highly sensitive "integromics" promise a precise documentation of stable polyclonality, clonal fluctuation or clonal imbalance of gene-modified cell populations.

However, in a low transmission area such as Lao PDR, no clonal fluctuation in allelic types are observed in P. falciparum clinical isolates, with monomorphic bands observed for all three major msp1 allele types [ 34].

Nonetheless, for S. pyogenes, these correlations are not always clear, primarily because of frequent clonal fluctuations for this organism.

This suggests that individual populations or yearly environmental conditions drive fluctuations in heterozygosity via clonal amplification rather than specific geographic or biotypic effects.

However, the number of loci that deviated from HWE decreased when populations were grouped according to biotype or sampling cluster, suggesting that individual populations or yearly environmental events drive fluctuations in heterozygosity via clonal amplification rather than any specific effects of geography or biotype.

Whereas before, the tumors were clonal, "now we're seeing slight variation — slight chromosomal differences.

However, stem cell populations tend to be small and therefore clonal expansion of mutant cells is highly sensitive to stochastic fluctuations.

To elucidate the role of PD1 and PD-L1 in the mechanism of these two distinct states alternation, PD1 and PD-L1 expression were analyzed longitudinally in present study throughout the immune clearance phase; and the changes of PD1 and PD-L1 expression were related to HBV -specific T-cell clonal expansion, proinflammatory cytokine expression, serum ALT, HBV-DNA and HBs-Ag fluctuation.

For example, the intensity of demographic fluctuations depends on latitude [ 44], whereas the rate of clonal turnover would positively correlate with the sympatric occurrence of a sexual ancestor [ 13].

Stochastic fluctuations were observed in passenger mutation numbers (Fig. 2C), as clonal expansion of passengers was caused by their hitchhiking along with a clone that had acquired a new driver mutation.

It is unknown whether the clonal expansion of cells containing genetic abnormalities is always due to positive selection or reflects stochastic fluctuations in the numbers of HSC progeny or cycles of quiescence and active contribution to haemopoiesis by different HSCs.