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In fact one may argue that following a period of intense and rapid clonal dispersion, USA300 has now entered a period of development of a polyclonal lineage rather than a single dispersing clone, which was also suggested by Kennedy et al [11].
The clonal dispersion from individual Tbr2 positive intermediate progenitors contributes to increasing the cortical surface.
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Furthermore, a clonal analysis of the dispersion of EGFP expression revealed that the IFN-SAR/5′HS4 insulator dyad was particularly effective in reducing the variability of transgene expression when both sequences were placed in opposite orientations within the retroviral backbone.
In contrast, the measured increase in the dispersion of the clonal ribbons around the crypt circumference in adenomas is not compensated by the reduction in the migration speed, and translated to an acceleration of the loss/replacement rate by a factor of approximately two.
We also describe the laminar dispersion of clonally derived cells from IPCs using a recently described clonal analysis tool (CLoNe) and show that pair-generated cells in different layers cluster closer (142.1 ± 76.8 μm) than unrelated cells (294.9 ± 105.4 μm).
Whereas the anterior clonal cluster displays relatively more tangential dispersion and contributes predominantly to nuclei with cognitive functions, the medial ventral posterior clonal cluster forms prominent radial arrays and contributes mostly to nuclei with sensory- or motor-related activities.
Such an immune-mediated patho-mechanism would depend on sufficient time for the clonal selection, migration, homing and peripheral dispersion of immune cells.
The previously reported observation of slower improvements in symptoms suggestive of FD and IBS could hint to a primarily immune-mediated, rather than neural, etiology, which potentially relies on the known time-requiring steps involved in clonal selection, migration, homing and peripheral dispersion of immune cells.
B-cell clonality studies showed no predominant clonal rearrangements.
These findings suggest a clonal strategy involving a mechanism that distributes cells longitudinally, then a mechanism that arrests cell dispersion and produces oriented stripes, followed by a mechanism that shifts oriented growth to isotropic growth.
Clonal distributions.
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