Sentence examples for clonal development from inspiring English sources

More specifically, we examined how global gene expression patterns differed in cells that were co-developing with other cells of identical genotypes (clonal development) vs. other cells that were genotypically distinct (chimeric development).

Occasionally, whole microcolonies were observed to be fluorescent, adjacent to microcolonies of similar size and density that were non-fluorescent (Figure 1D), indicating that FIMS had occurred at an early stage during the clonal development of the microcolony.

Clonal development was found to be morphologically identical to that of the wild type.

Once clonal development evolved, genetic uniformity was selected for through a single cell bottleneck.

Subsequently, clonal development became a selective advantage by short-circuiting reproductive dispersal of individual cells.

This may require an explanation in the context of clonal development.

These two distinct types of cancer can both be multifocal, but the extent or pattern of clonal evolution during development seems to differ between them.

Acquisition of somatic mutations and chromosomal aberrations is a hallmark of cancer development and clonal evolution of cancer cells [24].

Future studies examining mutation profiling on a single-cell level (Greaves, 2009) would reveal a complex clonal evolution in melanoma development and progression.

Although these genetic diversities occasionally emerge in clonal evolution during tumor development 22, it is conceivable that individual tumors are derived from independent progenitor cells.

These changes ultimately result in uncontrolled cell growth and clonal tumor development.