Sentence examples for clonal change from inspiring English sources

First, invasive UCa may represent a default pathway of bladder cancer development, with clonal change resulting in SCCa development and overgrowth of a pre-existent UCa.

Six of the patients developed a paraprotein different from that at diagnosis during CR or plateau phase and, hence, a "clonal change".

However, clonal changes did not persist, but reverted to the standard Gaussian peak at 15 DPI.

Clonal changes in chromatin may result from epigenetic modifications occurring during lymphocyte differentiation.

Clonal changes consistent with clonal selection by the treatment were seen in a subgroup of patients.

But the overall extent of clonal changes in glioma genome has not been reported.

These cancers are generally considered to result from the accumulation of multiple clonal changes in genes that regulate cell growth and differentiation [ 3, 4].

The close correlation between older age and other negative risk factors, such as the number of clonal changes and high-risk abnormalities, should be considered.

A detailed study was performed in 14 patients with epithelial ovarian tumours using the satellite probes 33.15, 228S and 216S to investigate the nature of somatic changes and frequency with which clonal changes could be demonstrated during metastasis and progression.

Subsequent sampling will be needed to study the further evolution of the pneumococcal population, to document clonal changes within serotypes and the emergence of additional non-vaccine serotypes with the increased uptake of PCV-13.

Although DNA from peripheral blood cells or buccal cells would have prevented such possibility, recent evidence suggests that the detection of clonal changes in normal tissue found adjacent breast tumours would be unlikely [ 21, 22].