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No sedimentation or clogging of the cells was observed in the circulation system of the liquid phase during shake-flask culture.
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The EDTA also prevented clogging of the nozzle during sorting.
There was no obvious decrease in mass fluxes, indicating no fouling or clogging of the membrane.
The technique is similar to the parylene-C-coated device except that the pores are more optimized and the conical shape of the pores makes it more effective to avoid clogging of blood cells.
Layers cracking, clogging of mesh cells are not observed.
This tissue morphology is consistent with "clogging" of lymphatic vessels by B cell aggregates and resultant, diminished lymphatic flow as observed in collapsed vs. expanding PLN.
Moreover, the high concentration of blood cells can easily cause clogging of microscale constriction or filter structure designed for cell sorting in microfluidic devices, compromising their performance for applications involving whole blood samples.
Malfunctions in the cells' protein-disposal machinery can lead to the accumulation of misfolded proteins, which clog up the cell, interfere with its functions, and, over time, precipitate the development of diseases, including neurodegenerative conditions such as amyotrophic lateral sclerosis and Alzheimer's.
Stanford University biologist Ron R. Kopito recently showed that clumps of the Huntington's protein can clog up the cell's waste disposal system.
That causes potassium carbonate to build up, slowly clogging the cell's air pores.
The robustness of this device was assessed by propagating an E. coli strain under permanent thymine starvation for over 880 days, i.e. metabolic conditions notoriously known to lead to cell death and clogging of cultivation vessels.
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