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In addition, stopping of the circadian clock linked to low winter temperatures could in part explain the extensive remodeling of meristem transcriptome observed in the vascular cambium of poplar during the transition from growth to dormancy [44] [47].
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The distinctive square studio clocks, linked to an electrical master clock, were designed by Mackintosh himself.
The 19 distinctive square studio clocks are linked to a master clock which should send an electrical pulse ensuring they all show the same time.
Disruption of the circadian clock is linked to several medical disorders in humans, including depression, insomnia, cardiovascular disease, and cancer, says Paolo Sassone-Corsi, chairman of the Pharmacology Department at the University of California, Irvine, who has done extensive research on the circadian clock.
Throughout, Eltham was set up with "mod cons" (as modern conveniences were known) like an internal telephone system and a clock linked directly to the Greenwich observatory.
The network structure for the final iteration is shown in Figure 5. Notably, all the clock genes are linked to at least one other clock gene and more extensively linked to each other than to other network components.
This mismatch between the environment and the internal body clock has been linked to negative outcomes such as sleep deprivation and chronic fatigue.
Disturbance of the circadian clock has been linked to cancer; specifically, deregulation of Per1 and Per2 have been connected to gastric cancer and suggested as prognostic markers [49-51] [49-51]
Disruptions of the biological clock has been linked to the development of certain cancers.
The circadian clock is also linked to metabolism.
CLOCK was recently linked to aging induced by non-lethal irradiation in mice [ 16] In accordance with its central role in the circadian system, mice with a mutation in the Clock gene lose circadian behavior and have a disrupted pattern of circadian gene expression [ 17, 18].
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