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The timing of the circadian clock is maintained by a set of genes and proteins that form a feedback loop ("clock" genes) as well as rhythmically regulate many output genes (clock -controlled genes).
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Robustness focuses on how a biological function, such as the phase of a particular clock component, is maintained under varying conditions.
In mammals, the master clock for circadian rhythm is maintained in the suprachasmatic nucleus (SCN) in the brain, but many peripheral organs maintain semi-autonomous clocks that can be set using signals from the SCN or other signals, such as nutrient status.
Given the perpetual self-renewal/regenerative nature of the intestinal epithelium, it will be interesting to determine whether clock regulation of cdx1b is maintained in the adult intestine.
TIMELESS is a core circadian clock gene in Drosophila melanogaster and is maintained in mammals, but its role in mammalian circadian clock function is not clear.
This helps to assure that a therapeutic blood level of the drug is maintained round the clock.
During these events round the clock service was maintained by OVPF.
The primary hypothesis being addressed in this paper is that temporal organization of peripheral clocks may be maintained in vivo by light and/or feeding cues, when the master clock in the suprachiasmatic nuclei is genetically altered.
The metaphorical clock, which has been maintained since 1947, is a summary view of leading experts who are deeply engaged in conversation around the existential challenges of our time.
Properly functioning circadian clocks confer fitness benefits (Dodd et al. 2005; Green et al. 2002), putting strong selective pressure on clock genes to be maintained in a stoichiometrically balanced fashion.
While components of the endogenous clock and their associated circadian clock mechanisms have clearly been maintained across diverse plant species, clock-mediated signaling has evolved in response to differing selection pressures.
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