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The peaking of expression at ZT14 and ZT22 coincides with phase shifting 'susceptibility windows'; time periods in which the photic input permits phase shifting (or 'resetting') of the clock (Ding et al., 1994; Iyer et al., 2014).
The associations of two additional genes, CR88 with JIC/USC and TIC with JIC4W, need further evidence, although both genes were a priori candidate genes involved in the light-dependent pathway (Cao et al. 2000) and the circadian clock (Ding et al. 2007).
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"My grandmother always said a clock rings ding and dong, not ding-ding-ding.
We previously reported work establishing mice lacking the clock gene D-box binding protein (DBP) as a stress-reactive genetic animal model of bipolar disorder.
We previously described the identification of clock gene D-box binding protein (DBP) as a potential candidate gene for bipolar disorder [ 6] using a Bayesian-like approach called Convergent Functional Genomics.
Ding, ding, ding, ding.
Ding, ding.
Ding, ding.
Ding, ding, ding -- Clonk!
Ding, ding, ding.
The bell goes ding, ding, ding, ding.
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