Exact(3)
A simplified model of the clock comprises three basic components: an input pathway that senses light, a core oscillator that is the transcriptional machinery defining the rhythms, and output pathways that control various developmental and metabolic processes, resulting in the appropriate physiological adaptations to the day-night cycle (reviewed [1], [2]).
The circadian clock comprises a hierarchical network of transcriptional, translational, and post-translational events that govern a tightly controlled timekeeping system.
Although the circadian clock comprises a highly interconnected network of transcriptional activators and repressors, this adaptation to a rhythmic environment has been maintained while the expansion of gene families and whole-genome duplication or triplication events have altered the balance between different clock components.
Similar(57)
Ghostwritten, number9dream, Cloud Atlas, Black Swan Green and The Thousand Autumns of Jacob de Zoet (not to mention his forthcoming novel The Bone Clocks) comprise a serious body of work.
In Arabidopsis, TOC1/ PRR1, LHY and GI, key component factors in the central clock, comprise interlocked transcriptional feedback loops to regulate plant circadian rhythms [ 12].
GI is regulated by the central clock oscillator comprised of TIMING OF CAB EXPRESSION 1 (TOCIRCADIANADIAN CLOCK ASSOCIATED 1 (CCand and LATE ELONGATED HYPOCOTYL (LHY).
The epigenetic clock is comprised of over 300 sites in our DNA that are subject to a certain chemical modification known as methylation, which physically prevents those sites from being expressed (i.e., turns them off).
The early models of plant clock regulation comprised reciprocal regulation of TOC1 by the partially redundant Myb transcription factors LHY and CCA1 while expression of these two genes was in turn repressed by TOC1.
Mammalian circadian clocks are comprised of populations of coupled circadian oscillators (clock cells) (Colwell, 2000; Mohawk and Takahashi, 2011).
The positive limb of the mammalian clock machinery is comprised of CLOCK and BMAL1, which are transcription factors that heterodimerize through the PAS domain and induce the expression of clock-controlled genes by binding to their promoters at E-boxes.
This rhythm is established by a cellular clock mechanism that comprises interacting transcriptional feedback loops [ 22].
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