To continue with the clock analogy, it's as if you're transferring the setting of one clock to another without ever looking at the first clock.
The clock analogy stems in part from the fact that C. elegans has a homolog of the period circadian clock gene, lin-42, which, when mutated, slows developmental timing (Jeon et al. 1999; Monsalve et al. 2011).
Thus, all these events appear to occur under a genomic clock, by analogy to the traditional molecular clock of sequence evolution [ 59].
In analogy with real clocks, the circadian clock is not the product of a single gear, but rather composed of a series of interlocking movements that involve, at its core, both E-box binding proteins such as BMAL1 and CLOCK, along with hormone response element binding receptors REV-ERBα/β and the RORs.
In happier days Stuart Lancaster would measure England's progress by using the analogy of a clock face.
Cell divisions and therefore replication errors occur in many tissues, and by analogy to species molecular clocks, a reliable somatic cell molecular clock should allow comparisons among tissues.
Although the use of timekeeping analogies to advocate the argument from design were proposed long before Paley (e.g., John Ray had earlier used an analogy based on a clock to argue for natural theology, much like Cicero had used an analogy involving a sundial to make the same argument), the argument presented by Paley remains a classic exposition of the argument from design.
"Their intelligence, experience, vigilance, their clout in the hierarchy and the simple analogy of 'having a clock' is irrelevant if you never look at it or don't look at it frequently".
Once you venture into a business, you need to put enough points on the board and then manage the clock (told you I liked sports analogies).
Remarkably, we see the same genes upregulated by the circalunar clock in Platynereis, raising the possibility that, in analogy to Drosophila, an increase in RNA levels of Platynereis clock can account for the upregulation of period, pdp1, and timeless transcript levels, and in consequence for the significant shortening of the circadian behavioral period length of the worm.
