Sentence examples for clock alterations from inspiring English sources
Changes in biological rhythms are generally caused by one of three conditions: altered phase timing of the endogenous clock, alterations of the effector mechanisms, or external influences [ 26].
Since synovial fibroblasts were derived from chronically inflamed tissue, molecular clock alterations are most probably programmed for a longer period of time.
In addition, many circadian clock mutants exhibit alterations in flowering time associated with defects in day length perception [ 10].
In this longitudinal study, undertaken on 7098 participants of the PREDIMED trial, we have been able to demonstrate the relevance of the CLOCK-rs4580704 SNP in the incidence of T2D and related processes, which finally lead to a higher incidence of CVD in T2D subjects, strengthening the connection between genetic variants in core clock genes, metabolic alterations and CVD risk.
Expression alterations of clock genes are associated with key oncogenic pathways, patient survival, tumor stage, and subtype in multiple cancer types.
We systematically characterized the alterations of clock genes across 32 cancer types by analyzing data from The Cancer Genome Atlas, Cancer Therapeutics Response Portal, and The Genomics of Drug Sensitivity in Cancer databases.
It also appears that key components of the molecular clock are affected by alterations in metabolic activity.
The circadian behavioral phenotype of HAB mice is associated with specific alterations in clock gene expression in the hippocampus.
A possible reason for this discrepancy with Resende et al. is that we culture explant pairs for 3 hr whereas they observed delays to somite formation, in the absence of Shh signalling, only after 7.5 hr culture and alterations to clock gene expression after 4.5 hr culture.
These changes mostly consisted in phase shifting, and reduced amplitude for some clock gene oscillations, without alteration in the overall waveforms at our time resolution.
Taken together with our data, this indicates that PTH may reset the circadian clock of cartilage through alteration in levels of expression of Per mRNA and protein.
