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In addition to the intrinsic decline of the chondrocyte clock, age-related changes in the systemic cues from the SCN may contribute to the dampened cartilage rhythm.
With more than three clocks, age estimates change less rapidly.
This hypothesis explains satisfactorily the distribution of many stygobiont crustaceans and is testable by collating a phylogenetic framework and molecular-clock-age estimates of relevant clades, with their respective geographic distributions [ 2, 20].
Epidemiological studies into sleep disorders and OA risks of the elderly population would further illuminate the functional links between human body clocks, ageing and OA.
Who could not be drawn to the swimmer Dara Torres's attempt to hit the snooze button on the biological alarm clock at age 41? On Saturday, China's gold rush was postponed when Katerina Emmons of the Czech Republic defeated, among others, the 2004 Olympic champion in the women's 10-meter air rifle, Du Li.
Recently, connections between the circadian clock and aging have been established through the analysis of aging in model organisms with targeted disruptions or mutations in different circadian clock genes [ 7].
Recent data obtained in model organisms link the circadian clock with aging: in mice, deficiency of BMAL1 results in accelerated aging [ 9, 10], while deficiency of PER1 and PER2 and a mutation in CLOCK leads to the development of premature aging only after exposure to non-lethal doses of gamma radiation [ 16, 24].
Essays: The Sciences, for "Clock of Ages" by Brian Hayes.
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