The interactions among the mammalian circadian clock, acute seizures, and chronic epilepsy are not well-characterized.
Whereas most studies supporting a link between the circadian system and regulation of the cell cycle involve genetically disrupting the circadian clock, acute global temporal disruptions (e.g., jet lag) dysregulate the core clock mechanism without permanently altering molecular pathways [1].
A recent finding of targeting BMAL1 and CLOCK for acute myeloid leukemia (AML) therapy indicates further the pro-cancerous option of clock components (Puram et al., 2016).
Days and weeks later, we were treating dozens of responders around the clock for acute respiratory problems.
It is becoming clear that a senior consultant presence is required seven days a week and even, possibly, around the clock for acute care.
They were playing without per move increments, so Karjakin later got into acute clock trouble and blundered just before move 40.
While the mammalian circadian clock can adjust to acute phase shifts in the light∶dark cycle, this adjustment requires several cycles to re-establish the relationship between the environment and the internal clock [44].
In humans, deregulation or polymorphism of Per1, Per2, Cry2, Npas2 and Clock is associated with acute myelogenous leukemia, hepatocellular carcinoma, breast, lung, endometrial and pancreatic cancers, and non-Hodgkin's lymphoma [12], [33], [34], [35], [36], [37], [38], [39], [40], [41].
In the absence of acute damage, clock mutant ISCs divide normally and have no ISC-autonomous phenotypes.
For example short term "around the clock" analgesia dosing for acute pain, or "as needed" analgesia for intermittent pain.
Especially in a hospital destined for emergency care and acute polytrauma treatment, emergency situations need an active, skilful ICU service available around the clock.
