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No combinations proved clinically useful values according to Yuoden's index.
The differences were small but significant and were derived from clinically useful values.
No combinations reached however high and clinically useful values according to Youden's index.> -wrap-foot>> -wrap-foot>> -wraSignificantlyp-foot> aSignificantly different from follow-up group (p < 0.05).
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This translated into an ROC AUC of 0.7639 (see Additional file 3), which is below the clinically useful value for diagnostic purposes.
Secondly future research should focus on combinations of markers as predictors and combinations of tests such as serum screening markers and uterine artery Doppler [ 154] to improve the predictive accuracy to a clinically useful value.
The contribution is not in itself sufficient to achieve cost-effective, clinically useful value, even among highest NPC risk normal family members of multiple case families [34], let alone in the general population, since only a small proportion of infected individuals present with EBV-specific IgA seropositivity, but it does provide a majority biomarker contribution to early detection [28].
Consequently, our study population of 91 was insufficient to calculate clinically useful cutoff values with narrower 95% CIs and to compare usefulness of max-IMT, ABPI, and baPWV.
Since we enrolled a skewed population, we did not attempt to identify clinically useful cutoff values that could be validated in future studies.
Analysis involved binary logistic regression to identify predictors and provide regression equations and receiver operating characteristic curves to determine clinically useful cutoff values.
The aim of this study was to analyse the relationship between HCMV DNA and pp65 antigenemia levels in order to identify clinically useful threshold values for the management of patients.
Indeed, the fairly large inter-patient variability observed in absolute variations of Doppler parameters induced by the SBT precluded the determination of a clinically useful threshold value.
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