Sentence examples for clinically tolerable from inspiring English sources
The levels required for alkylating-agent sensitization exceed the clinically tolerable level of theophylline, and probably approach the tolerance of man to caffeine.
It is still unclear whether high levels of cytokine production may be necessary for efficacy of an rCTL agent and what the clinically tolerable level of cytokine release might be (Lum and Thakur, 2011).
Our findings thus suggest that if PaCO2 is clinically tolerable, EIP prolongation in ARDS provides physiological benefits including a small and consistent decrease in Vt which may help decrease dynamic strain [39].
Tissue engineering of an elastic cartilage graft that meets the criterion for both structural and functional integration into host tissue, as well as allowing for a clinically tolerable immune response, is a challenging endeavour.
Collectively, our data indicate that the intravenous infusion of rhLK8 at therapeutic doses may induce renal toxicities, such as acute TIN, but these toxicities are clinically tolerable and reversible with close monitoring and a recovery period.
Toxicity profiles were generally clinically tolerable.
In particular, octasaccharides completely inhibited these biological activities at 10 microg ml-, a clinically achievable and tolerable concentration.
The maximal effect of the dual PI3K and MEK inhibition can be achieved with alternative dosing schedules which are potentially more tolerable clinically.
Additional targeting of vascularised tumours likely occurred through the circulation as clinically relevant and tolerable drug plasma levels were achieved in the PTXePC-treated group (range of 12 31 ng ml−1 in all animals).
Potentiation of tamoxifen by the HDAC inhibitor vorinostat has been shown in preclinical models at clinically achievable and tolerable concentrations (Kelly et al, 2005; Hodges-Gallagher et al, 2006; Galanis et al, 2009; Munster et al, 2009b).
Combining panobinostat with azacitidine was tolerable and clinically active in high-risk MDS/AML patients, warranting further exploration.
