Sentence examples for clinically target from inspiring English sources
Clinically, target occupancy can be used to unequivocally confirm "drug-on-target" (proof of mechanism), (Morgan et al. 2012) guide clinical dose selections, and enable data-driven clinical "Go/No Go" decisions depending on whether the onset of side effects occurs prior to or after desired target occupancy range for efficacy (Wong et al. 2009).
While most therapeutics used clinically target proteins, RNA research is revealing a wealth of potential RNA targets, including splice sites.
This is attributable to the low bioavailability of statins in bone, as all of the current statins used clinically target the liver.
To test whether the use of an evidence retrieval system that uses clinically targeted meta-search filters can enhance the rate at which clinicians make correct decisions, reduce the effort involved in locating evidence, and provide an intuitive match between clinical tasks and search filters.
V100 and D90 should be over 95%andd 144Gy respectively for the clinically targeted volume [ 11, 12].
Which cells should be clinically targeted for the treatment of NP degeneration therefore remains unclear.
CTLA-4 was the first negative regulatory checkpoint receptor to be clinically targeted.
Therefore, only a small fraction of tumour cells are required to strain positive by IHC (immunohistochemistry) in order to be considered for clinically targeted therapy [ 110].
The strategy of clinically targeting cancerous cells at their most vulnerable state during mitosis has instigated numerous studies into the mitotic cell death (MCD) pathway.
This suggests the appropriateness of programs at all levels (national and clinically targeted) designed to reduce perceived stigma, including those publicising the actual levels of personal stigma.
The approach for new queries is to first translate the clinically targeted AQL-queries to other native storage targeted query languages (such as SQL, SPARQL, or XQuery [ 26]) and then run the query natively in the database.
