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A variety of other conditions have been reported, but, in most cases, their exact relationship to the electrical accident is unclear or cannot be clinically substantiated.
This pharmacologic advantage has been clinically substantiated in randomized, controlled trials comparing IV lorazepam with placebo [ 40], IV diazepam [ 41– 43], and IM midazolam [ 44].
In choosing therapeutic strategies the leading approach should be a clinically substantiated and differentiated approach based upon the clear verification of the present mental disturbances and upon assessing the register of psychopathological disorders including the differentiation of negative and positive symptoms, and of endogenous and psychogenic compounds.
Without clinically substantiated potential risks, these patients should experience the benefit of overall better quality of vision, reduced glare disability at least in some conditions, and better protection against retinal phototoxicity and its associated potential risk for AMD.
In summary, blue light-filtering IOLs have no clinically substantiated risks and have potential to create the benefits of better vision and reduced glare, and may have a protective effect against retinal phototoxicity and the development and progression of AMD.
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Similar findings were obtained in a study conducted in Russia [ 37], which showed that the use of ranolazine in patients with > 3 attacks of angina pectoris per week was clinically and economically substantiated.
The DSM-III criteria for post-traumatic stress disorder (PTSD) were derived clinically and have been substantiated in the literature only by self-report data while evaluation of these same criteria with more objective measures has been overlooked.
Along the same lines, indices of RH could be used to test whether the therapeutic intervention is having the intended physiologic effects and clinical benefits, thereby substantiating a clinically relevant mechanistic pathway.
Data from these studies were further substantiated in a clinically relevant model of spontaneous metastatic mammary carcinoma induced to develop arthritis.
The evidence supporting these nutritional goals is based on surrogate outcomes and is not yet substantiated by patient oriented, clinically meaningful endpoints.
By using the clinically established COX-2 inhibitor celecoxib, we substantiated the functional role of COX-2 as a downstream mediator of c-Rel and NFATc2-mediated TRAIL resistance.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com