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Results suggested a clinically significant response shift in ratings of most and average fatigue of approximately one-half standard deviation.
Results: Results showed that out of 25 patients treated with OEP, 64% had a clinically significant response after three months of treatment, compared with 92% with topical NSAIDs.
Thus, it is likely that stratifying patients first by Topoisomerase IIA expression before the application of genomic predictors of chemotherapeutic response may improve the ability of the classifiers in predicting clinically significant response to adriamycin.
If stable disease was included, the overall "clinically significant" response rate was 90%.
A decline in the PHQ-9-score of at least five points will be taken as a clinically significant response.
The clinically significant response level can be reviewed to some degree, although this study was not designed to clarify it.
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Those that are available offer only marginal benefits overall, but are associated with clinically significant responses in as yet undefined subgroups.
Olnes et al. [ 7] observed clinically significant responses in erythroid, neutrophil, and platelet lineages, with normalization of bone marrow cellularity and trilineage hematopoiesis after eltrombopag treatment.
Mavrilimumab induced rapid clinically significant responses in RA subjects, suggesting that inhibiting the mononuclear phagocyte pathway may provide a novel therapeutic approach for RA.
However, clinical trials of a number of different TRA agents proved generally disappointing with very few clinically significant responses in patients receiving the monotherapy or chemo-combination with the TRA agents.
The selection of the population of interest may be determinant: Grunberg et al. [ 30] observed significant responses in males and in premenopausal women, and further studies focusing on this population may help in detecting clinically significant responses deriving form mifepristone treatment.
More suggestions(18)
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