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The second study [ 5], a prospective clinical trial, showed the CLASI to be clinically responsive to change in disease severity over time.
We focused on cystathionine β-synthase (CBS) because of its clinical relevance in homocysteine metabolism and because some variants of the enzyme are clinically responsive to increased levels of its B6 cofactor.
Measuring early onset, however, requires a sensitive and clinically responsive measure.
Measuring early onset, however, requires a sensitive and clinically responsive tool.
Notably, no single gene was able to consistently discriminate between clinically responsive and resistant tumor samples [ 9].
Among those, 2 cases suggested a causative role of HSV-1 as the sole agent causing pneumonitis that proved clinically responsive to antiviral treatment.
Similar(51)
While the questionnaires have been developed and tested to assess cancer-specific symptoms, disease symptoms of interest are embedded in large, longer QOL questionnaires and cannot readily be aggregated into clinically relevant, responsive symptom indices.
Fifteen tumours with < 50% volume reduction over three months of treatment were classified as being clinically non-responsive.
A symptom reduction of at least 25% was considered clinically significant and "responsive" to TMS as per previous research [39].
A literature review based on 19 methodological studies [ 13], concludes that COPM is a valid, reliable, clinically useful and responsive outcome measure.
However there is a lack of evidence regarding which clinical tests are most responsive to clinically important change over time.
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