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Clinical signs, serological responses and the presence or absence of Borrelia spirochete DNA in skin biopsies were also measured to provide broad and clinically relevant measurements of response to treatment.
In this study, we developed a new phantom to produce clinically relevant measurements to study the performance of PSF reconstruction algorithms for the quantification of small sub-centimeter lesions in direct contact with surrounding tissue.
Future studies must incorporate human participants to determine the reliability and validity of this instrument at assessing clinically relevant measurements of human shoulder joint function with special attention placed on abduction higher than 90°.
All hip regions were included because the total hip is a composite of femoral neck, greater trochanter, and femoral shaft regions, and reliance on clinically relevant measurements at the total hip and femoral neck can mask physiologic changes in other regions of the hip (4).
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We discuss an important risk for discordance between biodistribution, as typically measured by drug surrogate, and therapeutic outcome, as determined by clinically relevant measurement of drug function in a disease model.
Conclusions: The arthroscopic method of double-bundle inlay PCL reconstruction provides comparable stability to the open inlay using clinically relevant measurement tools both in the PLC intact or deficient state.
The Katz Index [ 37] is a clinically relevant measurement [ 38].
It relies on serum-PFC measurements at age 5, and serum concentrations of specific antibodies two years later as clinically relevant measures of immune functions.
For the markerless method, the greatest apparent migration observed about the three anatomical axes investigated was between −2.08 and 1.35 mm (SD≤0.88) for z-axis translation, and −4.57° to 7.86° (SD≤3.17) for Ry-axis rotation, which were well beyond out of the range of what is typically considered adequate for clinically relevant RSA measurements.
These observations show exemplarily that models of infectious diseases need to be adapted for the assessment of clinically relevant outcome measurements.
287 Trial investigators must often seek a balance between achieving a sufficiently long follow-up for clinically relevant outcome measurement, 122 288 and a sufficiently short follow-up to decrease attrition and maximise completeness of data collection.
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