Liston, D. R. & Davis, M. Clinically relevant concentrations of anticancer drugs: a guide for nonclinical studies.
Plaxco says proteins may be a better target for diagnostic purposes, because they tend to be detectable at clinically relevant concentrations in the blood.
The designed analogues were non-haemolytic and non-cytotoxic at their MICs and clinically relevant concentrations.
Aztreonam was combined with ciprofloxacin, gatifloxacin, levofloxacin, cefepime, ceftazidime and imipenem at clinically relevant concentrations.
Conclusions: Our study shows that clinically relevant concentrations of propofol induce c-Fos and down regulated Egr-1 expression via an MAPK/ERK mediated pathway.
Penicillin and erythromycin were tested at clinically relevant concentrations of 10 and 1 μg/ml, respectively, alone and in combination.
Conclusions: Clinically relevant concentrations of DMSO impair platelet activation by a thromboxane A2-dependent, COX-1-mediated effect.
We report that cardiac microtissues provide a high-throughput experimental model that is both able to detect changes in cardiac structure at clinically relevant concentrations and provide insights into the phenotypic mechanisms of this liability.
Although the primary target of lidocaine as a local anesthetic is the voltage-gated sodium channels1, lidocaine affects cell growth and cell death by modulating mitochondria function at clinically relevant concentrations.
The postsynaptic glutamate receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione 6-cyano-7-nitroquinoxaline-2,3-dione 6-cyano-7-nitroquinoxaline-2,3-dione 6-cyano-7-nitroquinoxaline-2,3-dione 6-cyano-7-nitroquinoxaline-2,3-dione 6-cyano-7-nitroquinoxaline-2,3-dione synaptic transmission.
Based on their catechol structure, both inhibitors are potential uncoupling agents, but only tolcapone shows this effect in vitro at clinically relevant concentrations.
