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We did not find a relationship between PaCO2 and JVO2 or AVDO2; however, PaCO2 was clinically maintained in a normal range.
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The present study, therefore, provides support for a potentially clinically relevant, maintained protection by PPC in patients.
They were all clinically healthy and maintained in standard environmental conditions of temperature (28.0 ± 2°C).
The second sensitivity analysis was used to determine the percentage of patients who maintained clinically meaningful pain improvements from pre-milnacipran exposure (≥30% reduction in VAS pain score).
The KS strains were clinically isolated and maintained at −80°C in Brucella broth (Becton Dickinson, Franklin Lakes, NJ, USA) containing 25% (vol/vol) glycerol.
For months 3 15, the dose of efalizumab could be escalated to 4 mg/kg per week for up to 4 weeks if clinically indicated, then maintained at 2 mg/kg per week.
Additionally, 81% of patients continuing on milnacipran maintained clinically meaningful pain response (≥30% improvement from pre-milnacipran exposure), compared with 58% of patients switched to placebo (sensitivity analysis II; P < 0.001).
Preliminary random testing of suspected carrier small ruminants in a heartwater-endemic area (Keneba) in The Gambia using a nested pCS20 PCR detected a 60% (n = 14) infection rate; moreover all samples collected from clinically sick goats maintained on-station at ITC (Kerr Seringe), and confirmed as heartwater cases post mortem, tested positive by the same assay (B. Faburay, unpublished data).
The magnitude of the analgesic effect is clinically meaningful and is maintained with repeated use.
In addition, over one third of patients maintained a clinically significant improvement in their pain.
Clinically cured ML patients maintained the production of IL-10, which was influenced by the disease duration.
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