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Thus, there is a critical and urgent need for chronopharmaceutical research (e.g., design and evaluation of robust, spatially and temporally controlled drug delivery systems that would be clinically intended for chronotherapy by different routes of administration).
Because oral administration is the clinically intended route for SST, it was administered by oral gavage in the present study.
A sufficient number of animals to guarantee reliable interpretation of the results should be treated and two routes of administration (the intravenous and the clinically intended, when different from intravenous) are recommended.
Hearing thresholds were measured twice through each of the 4 transmission paths: once using BC Direct, that is, measuring the BC thresholds with the sound processor as the signal generator, and once as aided sound field thresholds, where the sound processor acts as a hearing amplifier in its clinically intended way.
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While 18F FDG and 68Ga- or 18F PSMA ligands will most probably remain the workhorses for oncologic hybrid imaging in the foreseeable future, several other imaging probes are being developed and clinically tested, which are intended to cover clinical scenarios in which 18F FDG and PSMA ligands do not provide sufficient precision in tumor characterization.
Indeed, the sample was clinically referred and not intended to be representative of children with CD in the population.
The lack of clinical signs and the finding of paucibacillary lesions in the majority of goats indicate that this experimental model targets as intended the clinically non-apparent phase of infection.
Responsiveness is a necessary property of instruments intended for measuring clinically meaningful change, such as in stroke self-SMIs [ 74, 75].
This system classifies every hospital patient into one of several hundred DRG groups that are intended to be clinically meaningful and homogenous with respect to resource use.
1 The UK Department of Health is developing performance indicators for emergency and urgent care that are intended to be clinically credible and evidence based outcome measures.
Vignettes were not intended to be clinically complex and comprehensive practicals, but rather as purposely simplified evaluations of crucial, basic newborn care in the first day of life aiming to emphasise the most obvious gaps.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com